OTTAWA – A survey suggests most Canadians believe texting and driving is getting worse despite police crackdowns and extensive public education efforts.In the November survey conducted by the Canadian Automobile Association, 83 per cent of respondents said they believe texting while driving is a bigger problem now than it was three years ago.The CAA survey also shows a whopping 96 per cent of respondents say drivers who text and drive are a threat to their safety on the road and that texting and driving is now tied with drunk driving as the top road safety concern among Canadians.The CAA also says other forms of distraction are increasingly an issue, such as emailing while driving, drivers talking on cell phones and drivers talking to or interacting with their in-car technologies.The survey of 2,003 Canadians has a margin of error of plus or minus 2.19 per cent, 19 times out of 20.“Despite anti-texting and driving laws in all provinces across the country and several years of public education campaigns, Canadians still don’t seem to be getting the message,” said CAA chief strategy officer Jeff Walker.“Studies show drivers are as much as 23 times more likely to get into a collision when they text and drive. It’s important we all put our devices down and stay focused on the road,” he said.
VICTORIA — A British Columbia pediatrician who treats children and youth struggling with substance abuse issues says he supports placing young people in treatment facilities against their will if they have suffered an overdose.Dr. Tom Warshawski told a coroner’s inquest into the death of 16-year-old Elliot Eurchuk that an overdose is a life and death situation where a young person is being controlled by the potentially deadly drugs and is not in control of their thinking.Warshawski says committing young people to secure treatment facilities where they cannot leave for a time period at least allows doctors to help clean the drugs out of their systems and open their minds to the possibility of future treatment.Eurchuk died of an overdose in 2018 about two months after he was forcefully admitted to a Victoria youth treatment ward following an overdose at hospital while undergoing treatment for a blood infection common to intravenous drug users.Eurchuk’s parents, Rachel Staples and Brock Eurchuk, have testified efforts to help their son were thwarted by medical privacy laws that permitted withholding information about the teen’s addiction issues.Warshawski says he is part of a working group that has provided recent research documents about secure care treatment for young people to B.C.’s Ministry of Health and the Ministry of Mental Health and Addictions.Former B.C. provincial health officer Perry Kendall is scheduled to testify at the inquest.The inquest is expected to wrap up today after hearing from more than 40 witnesses over eight days.The Canadian Press
She said the issue is being addressed with government bodies including the Russian Finance Ministry. (Colombo Gazette) Russia is in talks with Sri Lanka on the credit purchase of Gepard-class Project 1166.1 frigates, the Gepard 5.1, Russia’s Federal Service for Military-Technical Cooperation (FSMTC) spokeswoman told Sputnik on Thursday.“The delivery of the project Gepard 5.1 to Sri Lanka is planned on the basis of an intergovernmental agreement on providing a state export credit for its financing,” Maria Vorobyeva said.
OSU freshman guard D’Angelo Russell (0) dribbles the ball up the floor during a game against James Madison on Nov. 28 at the Schottenstein Center. OSU won, 73-56.Credit: Samantha Hollingshead / For The LanternAfter securing five double-digit victories at home to begin the season, the No. 14 Ohio State men’s basketball team is set to hit the road to take on a top-five opponent.OSU (5-0) will look to pass a major test against No. 5 Louisville (5-0) in Louisville, Ky., on Tuesday.For the four freshmen in OSU’s rotation, including guard D’Angelo Russell, the game will mark the first on the road in their collegiate careers.“I’m definitely looking forward to the atmosphere,” Russell said.However, senior guard Shannon Scott said he has been stressing to the younger players to not think too much of Tuesday’s challenge.“It’s another game, really. At the end of the day, somebody’s going to have a win and somebody’s going to have a loss,” Scott said. “It’s not really a special game where we have to feel like if we lose this game we can’t play no more basketball for the rest of our lives.”Despite being an away game for OSU, the game will be played at home for Russell.Russell is a Louisville native, though he played his final three years of high school basketball at Montverde Academy outside Orlando, Fla.The freshman said he has had the game circled on his calendar all year, and is looking forward to playing in his hometown.“It’s definitely a dream come true, to either play with them or play against them,” Russell said.Russell, the leading scorer for the Buckeyes this season, said Louisville offered him a scholarship, but he preferred the “vibe” he felt when he visited OSU.OSU coach Thad Matta said Russell’s hometown school did not present a large obstacle in landing the 2014 McDonald’s All-American.“I don’t honestly remember Louisville being hot and heavy after him,” he said.Russell said he has played with several players on the Cardinals’ roster, including his former Louisville Magic AAU teammate and freshman guard Quentin Snider.Louisville comes into the game ranked fifth in the country in rebounding margin at +13.6 per game, while OSU ranks 64th.Scott said avoiding that trend would be a key for the Buckeyes.“We know Louisville’s one of the best, if not the best, rebounding team in the country, so we know we’re going to have to find a way to keep them off the boards,” he said.Matta agreed with his point guard’s assessment that a major key to the game will be the battle on the glass.“I think that they do a tremendous job of getting on the glass and not only getting put-backs but keeping the ball alive, knocking them out, those types of things. And they’re big. They have a very unique team in terms of how they play,” Matta said.Louisville has four players averaging more than 11 points per game, led by forward Montrezl Harrell.Matta had high praise for the junior, who is leading the team in points and rebounds per game.“He’s special,” Matta said. “He plays at a high level, a high motor, very energetic. He’s got a lot of different ways that he scores.”The coach had additional levels of praise for Louisville coach Rick Pitino, a two-time national champion.“I view coach Pitino as one of the all-time greats in this profession,” Matta said.However, despite the respect he has for the opponent, Matta said that the unselfishness coming from his starting backcourt of Scott and Russell has given him confidence that OSU can come out of Kentucky with a victory.“I love the fact that both D’Angelo and Shannon have had great command of our offense, and in a game like tomorrow night, they’re going to have to be able to do it,” he said. “They’re going to have to make quick reads and good decisions, and I feel pretty comfortable with their ability to do that.”Russell leads the Buckeyes in scoring with 18 points per game and has added 5.4 assists per contest, while Scott leads the nation in assists with 10.4 per game.Louisville and OSU each rank in the top-10 for longest active NCAA Tournament appearance streaks, at eight and six years, respectively. The Cardinals cut down the nets in 2013 after defeating Michigan in the championship game.Regardless of the result Tuesday night, Matta said that both playing on the road for the first time and facing an opponent as strong as Louisville will give him insight into his team moving forward.“Tomorrow night, at the conclusion of the game, we’ll know a little bit more about our team and we’ll be a better team coming out of it,” he said.Tip is set for 9:30 p.m.
A VIDEO FROM the helmet camera of a firefighter responding to the crash landing of an Asiana Airlines flight in San Francisco shows at least one rescuer was aware someone was on the ground outside the aircraft and even warned a colleague.Yet two fire trucks subsequently ran over an injured passenger.The video, first aired by CBS News on Tuesday, shows the girl, 16-year-old Ye Meng Yuan, lying in the grass before she was struck, according to an attorney for her family. A coroner concluded she was alive at the time and died when she was later hit by a fire truck.In the video, a firefighter with a helmet camera tells the driver of a fire truck that there’s a person in front of him. A fire truck-mounted camera shows a firefighter directing the truck away from the person.What’s not clear from the video is why rescuers didn’t try to move or clearly mark the presence of the person on the ground during the chaotic aftermath of the 6 July crash at San Francisco International Airport.(AssociatedPress/YouTube)The video, which was released to The Associated Press yesterday by attorneys for the girl’s family, reflected much of what officials have said, only with more detail.About 15 minutes after the driver of the fire truck was alerted to the girl’s presence, the video shows that same truck running over her, according to CBS. Footage of her being run over was not aired in the CBS News broadcast.The helmet camera shows another truck driving over her minutes after that, according to CBS News, which said it obtained the video from a person close to Yuan’s family.The San Francisco Chronicle first reported on the video’s content, but did not release the video publicly.It’s still unknown how Yuan got out of the plane.“At least five firefighters knew of her presence before she was covered in foam. Nobody examined her, nobody touched her, nobody protected her, moved her or did anything to take her out of harm’s way, and then they abandoned her there,” said Anthony Tarricone, an attorney for Yuan’s family, which has filed a legal claim against the City of San Francisco.San Francisco fire spokeswoman Mindy Talmadge said on she could not comment on the video because of the pending litigation.In all, 304 of the 307 people aboard the Asiana flight survived after the airliner slammed into a seawall at the end of a runway during final approach for landing.Read: Asiana chief defends ‘experienced’ pilots as investigators question themRead: Passenger survives plane crash while capturing it on camera
EACH WEEKDAY EVENING, TheJournal.ie brings you the five stories you need to know before you hit the road.1. #LABOUR: Tánaiste Eamon Gilmore has announced his resignation as the leader of the Labour Party.2. #EUROPE: Luke Ming Flanagan has topped the polls in the Midlands-Northwest constituency. Brian Crowley came out on top for Ireland South. Meanwhile a recount is taking place in the Dublin European elections after a request from Green Party candidate Eamon Ryan.3. #ELECTION: We’re into day three of counting in Election 2014 with the last few seats still to be filled. You can check out everyone elected in your area so far here.4. #TRAGEDY: A young man was found dead in a house in Donegal after a house party.5. #TAXES: TheJournal.ie has revealed that revenue demanded €200,000 in unpaid tax from the Paris Bakery in Dublin. Workers at the former bakery have been holding a sit-in since last week as they say they’re owed €55,000 in unpaid wages.
[via Gadjitz] If you think this is some kind of secret military project going on behind the scenes at DARPA, you’d be wrong: these how-to flamethrower gloves are actually the product of the special effects and design team at J&M Special Effects, who were interested in coming up with a system that could shoot real flame from a stage or movie set performer’s hands with very real effect. The guys at J&M note that the system is a prototype, and they’re not finished working on it: future iterations will be more compact and the hoses for the propellant will be streamlined and closer to the performer’s body so they can be hidden under clothing or a costume. The end result looks amazing, with the flame literally erupting from the palms of the wearer’s hands. Hit the jump to see the full video.
Landlords who evict tenants because they want to sell or renovate a property could face tough sanctions The Government proposals aim to increase the rights of tenants in the rental market. https://jrnl.ie/4577322 Thursday 4 Apr 2019, 6:11 PM 114 Comments 74,976 Views Image: Rollingnews.ie Tweet thisShare on FacebookEmail this article Minister for Housing Eoghan Murphy announced the propsals this evening Source: Rollingnews.ieThe proposals also introduce new sanctions to tackle improper conduct by landlords who break the provisions under which rental tenancies can be terminated.Landlords who terminate a tenancy because they intend to sell a property will now have to enter into a contract for sale within nine months of the date of termination, or offer to re-let the property to a former tenant if not.If a landlord terminates a tenancy because they wish to rent it to a family member, they must offer the property back to the former tenant if it becomes vacant again within a year of the termination date, rather than six months, as is the case under current law.Meanwhile, landlords who terminate a tenancy because they want to renovate a property must also offer it back to the former tenant when that work is completed.In this case, a certificate from an architect or surveyor will be also required to state that the proposed works would pose a health and safety risk requiring the property to be vacated, and that the works would require at least three weeks to complete.Murphy said that the new laws were necessary at a time while a supply challenge existed in the rental sector, which he claimed was developing into a more stable one.He added: “The reforms as a whole all favour tenants and give them greater protections, but we have to be careful not to undermine the supply of rental homes at the same time; that would only make things worse.”With additional reporting by Christina Finn Image: Rollingnews.ie LANDLORDS WHO EVICT tenants because they want to sell or renovate their property or let it to a family member could face tougher sanctions under new Government plans.The sanctions are part of a number of proposals aimed at increasing the rights of tenants in the rental market, announced by Minister for Housing Eoghan Murphy this evening.The plans include an extension of the time that Rent Pressure Zones (RPZs) are in place until the end of 2021, provisions for the regulation of short-term letting, and the expansion of legislation to increase the rights of those living in student accommodation.Murphy said the proposals were the most significant rental sector reforms in recent years, and would bring greater affordability and security for those in the renal market.“Not only are we now extending rent controls out to the end of 2021, we are also changing the criteria to capture more areas experiencing high rent inflation, and closing down avenues that allowed some landlords to escape rent controls,” he said.“In addition, we are strengthening security of tenure provisions for tenants, and also extending notice to quit periods.“This will help those in housing insecurity while also giving more time for people to find new accommodation where necessary.” By Stephen McDermott Share1782 Tweet Email15 Short URL Apr 4th 2019, 6:11 PM
MIAMI (WSVN) – A man riding a bicycle was rushed to the hospital after a car hit him in Miami, Tuesday morning.According to Miami Police, a man riding his bicycle was struck by a car near West Flagler Street and Southwest 27th Avenue, at 6 a.m.The bicyclist, who is described as an adult male in his 40s, soon went into cardiac arrest after being struck.He was transported by Miami Fire Rescue crews to Jackson Memorial Hospital with lacerations to the head and leg.The driver involved stayed on the scene.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Tags Post a comment See Spot twerk: Boston Dynamics robot dog can shake its booty Boston Dynamics robots rated by Robopocalypse threat level Enlarge ImageAstro looks ready for anything. Alex Dolce There’s a spectrum between cute and creepy when it comes to robot dogs. Sony Aibo: cute. Boston Dynamics SpotMini: creepy. We’ve finally discovered some middle ground: Florida Atlantic University’s Astro. Astro is a four-legged robodog that responds to voice commands. He can move forward, stop and sit on command and doesn’t have the urge to go chase squirrels. Robots Sony Share your voice Sci-Tech 18 Photos 0 Astro is trying to think like a dog thanks to artificial intelligence and deep learning technology in his computer “brain.” The research team behind the robodog wants to teach him to respond to hand signals, colors and multiple languages while also recognizing different people.The uses for a robot like Astro are many. He could sniff out explosives residue for law enforcement, act as a service dog or be an assistant for first responders. The FAU team, which includes psychologists, neuroscientists, artists and biologists, hopes to make Astro so smart he can make decisions on the fly based on a database of experiences.Unlike Sony’s dainty Aibo robopet, Astro isn’t much of a lap dog. He weighs 100 pounds (45 kilograms). He’s still in the equivalent of puppy school for robots, but he could grow up to be quite a bit smarter than the average robodog. The robots are coming Meet Boston Dynamics’ weird and wonderful robot family The robot’s anatomy mimics that of its real-life canine inspiration. “Astro is unique because he is the only one of these robots with a head, 3D-printed to resemble a Doberman pinscher, that contains a (computerized) brain,” FAU said in a release Wednesday. For comparison, Sony’s Aibo robot dog carries most of its electronics in its body and Boston Dynamics’ SpotMini has an optional extending neck, but can just as easily go headless.The university shared a video of Astro in action going for a stroll on a lawn.
Md Abdul Wahhab MiahActing chief justice Md Abdul Wahhab Miah on Monday apprised his fellow judges of the Supreme Court of the reasons behind the issuance of an SC statement on CJ Surendra Kumar Sinha.The acting chief justice explained the reasons in a full court meeting where all the judges of both the SC divisions were present, according to SC officials present in the meeting.Read more: Sinha to be sued if allegations found true: AnisulThe full court meeting was held in the Judges’ Lounge with the acting chief justice in the chair.At the beginning of the meeting, Abdul Wahhab Mia explained the context as to why the SC had to issue a statement a day after the departure of CJ Sinha.The chief justice flew for Australia on 13 October and the very next day the Supreme Court’s registrar general, Syed Aminul Islam, issued a statement, saying that the president, Abdul Hamid, brought 11 specific allegations of money laundering, financial irregularity, corruption and moral turpitude against SK Sinha.Read more: President raises 11 corruption charges against CJ SinhaAnd the fellow judges of the Appellate Division had declined to sit in the same bench with the chief justice following the allegations raised by the president, it added.The SC statement also termed misleading the statement chief justice SK Sinha had issued before leaving Dhaka for Australia on Friday, claiming that Sinha’s remarks (before the media) required it to issue the statement.Read more: Idiots call me a liar, Anisul about talk-show speakers
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further New DNA analysis thousand times more sensitive More information: Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell, Science, 21 December 2012: Vol. 338 no. 6114 pp. 1622-1626. DOI: 10.1126/science.1229164ABSTRACTKindred cells can have different genomes because of dynamic changes in DNA. Single-cell sequencing is needed to characterize these genomic differences but has been hindered by whole-genome amplification bias, resulting in low genome coverage. Here, we report on a new amplification method—multiple annealing and looping-based amplification cycles (MALBAC)—that offers high uniformity across the genome. Sequencing MALBAC-amplified DNA achieves 93% genome coverage ≥1x for a single human cell at 25x mean sequencing depth. We detected digitized copy-number variations (CNVs) of a single cancer cell. By sequencing three kindred cells, we were able to identify individual single-nucleotide variations (SNVs), with no false positives detected. We directly measured the genome-wide mutation rate of a cancer cell line and found that purine-pyrimidine exchanges occurred unusually frequently among the newly acquired SNVs. The genome of single cells has been sequenced before using a technique known as a polymerase chain reaction (PCR) to produce enough copies of the DNA for sequencing. This procedure enables researchers to sequence the genome with about 40-70 percent accuracy, but greater precision is difficult because of amplification bias, in which some parts of the genome tend to be copied more readily than others. Not only does this reduce the extent of the genome that can be sequenced, but it also means segments of DNA that are copied are difficult to detect and may be missed.In a paper published in Science a US research team describe a new way of getting around the amplification bias problem. The team, led by Professor X. Sunney Xie of Harvard University in Massachusetts, has developed a new technique which they have named “Multiple Annealing and Looping-Based Amplification Cycles” (MALBAC), in which the genome from a cell is first isolated and then “primers” consisting of short segments of DNA are added. When the DNA with the added primers is copied, up to 93 percent of the genome can be sequenced because the common segments incorporated into the copies loop back on themselves.The primers are pieces of DNA with a common section of 27 nucleotides and a variable section of eight nucleotides. The shorter section binds to the cell’s DNA and the longer, common section reduces amplification bias by preventing the DNA from being copied too often.The researchers used the new technique to sequence the DNA in three closely related cells, and also the DNA of 99 sperm from a single Asian male (as described in a second paper in the same journal). They were able to identify variations in individual nucleotides and observed no false positives.The improvement in single cell genome sequencing is a big advance, but variations in single nucleotides could still be missed. The copying method can also introduce occasional copying errors.The ability to sequence the genome in a single cell could help in cancer and other research since it would allow comparisons between individual cells. It could also prove useful in applications where only a small sample of DNA is available, such as in forensic science. Journal information: Science © 2012 Phys.org Citation: New method for sequencing genome in a single cell (2012, December 21) retrieved 18 August 2019 from https://phys.org/news/2012-12-method-sequencing-genome-cell.html (Phys.org)—The traditional genome sequencing process requires thousands of cells (or more) to provide sufficient DNA, and this means that variations that are only present in a small number of cells―such as early cancer cells―are missed. Now a new technique has been developed for effectively sequencing the DNA in an individual cell.
A large sample of native arsenic. Credit: Aram Dulyan/Public Domain This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Native people living in a part of the Atacama Desert in Chile (in a place known as the Quebrada Camarones, where it is drier than any other non-polar spot on the planet) are descended from settlers that moved into the area approximately 7,000 years ago. Those early settlers faced serious health problems due to very high concentrations of arsenic in the only water available. The researchers with this new effort suggest that many such settlers likely perished before they could produce offspring, leaving those that were more physically suited to dealing with the toxic metalloid to keep the population going. To find out how the modern people there are able to drink water that would seriously harm other people, the researchers collected blood from 150 of the local residents and subjected the samples to genetic testing. In particular, the researchers looked for variants of an enzyme called AS3MT—prior research has shown that people with such variants are better able to tolerate arsenic. The team reports that approximately 68 percent of the people they tested had such a variant. AS3MT breaks arsenic down into two compounds: monomethylarsonic acid and dimethylarsinic acid. Those with the stronger gene variant produce more of the latter.The researchers note that their results show that AS3MT variants are only part of the answer; 32 percent of those tested did not have the variant, which suggests there is some other factor at play. The next step, they suggest will be to sequence the whole chromosomal region around the variant that has been found to see if there are others that might be providing some sort of unknown resistance. Citation: Atacama Desert people found to have evolved greater tolerance of arsenic (2017, February 27) retrieved 18 August 2019 from https://phys.org/news/2017-02-atacama-people-evolved-greater-tolerance.html Study identifies first-ever human population adaptation to toxic chemical, arsenic Journal information: American Journal of Physical Anthropology Explore further More information: Mario Apata et al. Human adaptation to arsenic in Andean populations of the Atacama Desert, American Journal of Physical Anthropology (2017). DOI: 10.1002/ajpa.23193AbstractObjectivesQuebrada Camarones, in the Atacama Desert, has the highest arsenic levels in the Americas (>1,000 µg/L). However, the Camarones people have subsisted in this adverse environment during the last 7,000 years and have not presented any epidemiological emergencies. Therefore, to solve this conundrum we compared the frequencies of four protective genetic variants of the AS3MT gene associated with efficient arsenic metabolization, between the living populations of Camarones and two other populations historically exposed to lower levels of arsenic.Materials and MethodsThe Chilean selected population samples come from Quebrada Camarones (n = 50) and the Azapa Valley (n = 47) in the north and San Juan de la Costa (n = 45) in southern Chile. The genotyping was conducted using PCR-RFLP. We compared the genotypic and allelic frequencies, and estimated the haplotype frequencies in the AS3MT gene.ResultsWe found higher frequencies of the protective variants in those people from Camarones than in the other two populations. The haplotype estimation showed that the combination of protective variants of CTTA is very frequent in Camarones (68%) and Azapa (48%), but extremely low in San Juan de la Costa (8%). Also, the C variant associated with toxicity risks in the SNP Met287Thr had a lower frequency in Camarones (1%) and is higher in the other populations.DiscussionThe higher frequency of protective variants in both northern Chilean populations indicates a long exposure to naturally arsenic-contaminated water sources. Our data suggest that a high arsenic metabolization capacity has been selected as an adaptive mechanism in these populations in order to survive in an arsenic-laden environment. (Phys.org)—A team of researchers affiliated with several institutions in Chile has found that some people living in a part of the Atacama Desert have evolved over time for survival despite drinking water that contains 100 times the suggested maximum safe limit of arsenic as set by the World Health Organization. In their paper published in the American Journal of Physical Anthropology, the team describes a genetic study they conducted of the people in the area and what they found. © 2017 Phys.org
Feature | Prostate Cancer | April 10, 2017 | By Jeff Zagoudis Emerging Technologies in Prostate Cancer The next frontier is in detecting and treating recurrent prostate cancer The Status of Prostate Cancer ImagingThe majority of imaging research and advancements related to prostate cancer have centered around diagnosis and detection according to Peter Choyke, M.D., FACR, program director, molecular imaging program, senior investigator, head, imaging section, Center for Cancer Research at the National Institutes of Health (NIH). Issues of concern here include: • Risk assessment• Biopsy guidance• Staging• Surveillance• Focal therapy Technology | Interventional Radiology | August 16, 2019 Profound Medical Receives U.S. FDA 510(k) Clearance for Tulsa-Pro Profound Medical Corp. announced it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to… read more Following radiation, the bone marrow shows nearly complete loss of blood cells in mice (left). Mice treated with the PTP-sigma inhibitor displayed rapid recovery of blood cells (purple, right). Credit: UCLA Broad Stem Cell Research Center/Nature Communications As for metastatic disease, Choyke said advanced imaging work is just beginning in this area. Prostate-specific antigen (PSA) screening has appeared to lower metastatic disease rates (and by extension mortality rates), but currently the U.S. Preventive Services Task Force (USPSTF) recommends against it, saying the benefits are outweighed by the potential harms of overdiagnosis and treatment. As a result, more patients are again starting to present with metastatic disease. “This is the area that leads directly to death, so this would have a huge impact,” Choyke said. Imaging research related to detection and treatment of metastatic disease is centered on: • Imaging sensitivity• Disease response• Castration News | Proton Therapy | August 08, 2019 MD Anderson to Expand Proton Therapy Center The University of Texas MD Anderson Cancer Center unveiled plans to expand its Proton Therapy Center during a… read more Pomper noted that PSA cannot provide information related to the location or aggressiveness of cancer, and that conventional imaging has performed poorly for prognosis in castration-resistant prostate cancer (CRPC), further supporting the use of molecular imaging. Fludeoxyglucose (F-18) is the most commonly used PET agent for prostate imaging in the United States. It was predated by carbon-11, but that molecule features a three-minute half-life, making it not clinically translatable, according to Pomper. Conversely, F-18 features a longer half-life, making it easier to transport and mass produce domestically. “It also features a short positron path range, so you get a much crisper image,” Pomper said during his RSNA presentation. Challenges of PET/MRI. For hospitals looking to implement PET/MR for prostate cancer imaging, Choyke said the No. 1 challenge will be establishing a new workflow. “It is difficult to find technologists that are skilled in both PET and MRI,” he told his audience, “so you need two actively involved staff members.” This means that extensive training will be required for any kind of implementation, taxing critical resources of time and money. Further complicating the financial side, Choyke noted that the pay scale for technologists is often not adaptive to combined modalities. More than training differences, however, Choyke said that the culture of the two technologies is very different. “MRI typically is a modality that needs to be monitored very closely for image quality accounting for motion,” he explained, whereas PET imaging does not often require rescanning. From a safety perspective, MRI technologists are not used to working with radioactivity, while PET technologists may not be aware of the zoned safety approach required for MRI scans. “It is clearly a step forward in technology and the evolution of hybrid imaging,” Choyke said of PET/MR, “but the economic argument will have to be made for it if it’s going to be sustainable.” The MD Anderson Proton Therapy Center expansion is expected to be completed in 2023. Rendering courtesy of Stantec. Multiparametric MRIMagnetic resonance imaging (MRI) has proven to be one of the more effective imaging modalities for prostate cancer, helping improve localization and guidance of biopsies, especially for anterior cancers. According to Choyke, T1 and T2 stage disease that is confined to the prostate is easily detectable on MRI, while extra-prostatic disease (T3 and T4) are harder to visualize. Because of the disease’s variable nature, researchers and clinicians in recent years have started using multiparametric MRI (mpMRI), combining functional and anatomic imaging via several different sequences to provide a more complete picture. mpMRI exams typically include T2-weighted imaging for anatomy, diffusion weighted imaging (DWI) for cellularity and dynamic contrast-enhanced MRI (DCE-MRI) for vascularity. A number of clinical studies have assessed the effectiveness of mpMRI for prostate cancer, and have determined it is the best noninvasive alternative for tumor detection. One study, published in the Journal of Magnetic Resonance Imaging last July, looked to assess the performance of mpMRI as described in version two of the Prostate Imaging Reporting and Data System (PI-RADS). The research team found that mpMRI achieved 91 percent sensitivity in detecting clinically significant index lesions and 63 percent for all lesions across all readers.1 There has also been success in combining mpMRI with ultrasound to improve biopsy sampling. A study from the January 2015 Journal of the American Medical Association (JAMA) compared mpMRI/ultrasound-guided biopsy with standard biopsy; the image-guided biopsy diagnosed 30 more high-risk cancers than standard biopsy, and also diagnosed 17 percent fewer low-risk cancers, suggesting that targeted biopsies can help reduce overdiagnosis while still catching more developed disease.2 Related Content News | Radiation Therapy | August 15, 2019 First Patient Enrolled in World’s Largest Brain Cancer Clinical Trial Henry Ford Cancer Institute is first-in-the-world to enroll a glioblastoma patient in the GBM AGILE Trial (Adaptive… read more Technology | Radiographic Fluoroscopy (RF) | August 09, 2019 Shimadzu Medical Systems Receives FDA 510(k) for FluoroSpeed X1 RF System Shimadzu Medical Systems USA, a subsidiary of Shimadzu Corp., announced they have received U.S. Food and Drug… read more News | PACS | August 09, 2019 Lake Medical Imaging Selects Infinitt for Multi-site RIS/PACS Infinitt North America will be implementing Infinitt RIS (radiology information system)/PACS (picture archiving and… read more PET/MRIWhile PET and MRI each offer distinct advantages in prostate cancer imaging, many in the industry believe that combining the two can provide even greater benefits. Choyke noted that radiologists and researchers have been looking for the “killer application” for PET/MR since its inception, and prostate imaging has offered the most promising avenue thus far. “MRI is an important part of prostate cancer management, but numerous new PET agents provide high sensitivity and specificity for prostate imaging, so it makes sense to combine the two,” he told the RSNA audience. The real question, he said, is whether enough patients need simultaneous PET/MR scans to justify the $5-7 million price tag of these machines. Choyke further supported the utility of PET/MR for prostate cancer imaging by comparing it to PET/CT (computed tomography). One study published the previous January in the Journal of Nuclear Medicine found the two combination modalities performed equally well in lesion detection and image quality. The researchers did find, however, that PET/MRI was more accurate for anatomic lesion allocation within the prostate, which could have implications for biopsy planning.4One of the advantages of PET/MRI, Choyke said, is that with the full-body scanning capabilities of today’s MRI machines, it is possible to overlay PET images on top of the MRI scans for improved visualization. The combined modality has also demonstrated improved anatomic localization of recurrent lesions. Perhaps most importantly, however, Choyke said that PET/MRI has allowed a more sophisticated PSMA scan, which he said is highly accurate for early metastatic disease. “We’ve been able to look at both primary tumors and recurrent cancers,” he told the RSNA audience. There is limited data beyond this for PET/MR with metastatic disease, but more studies are ongoing and on the horizon. References1. Greer, M.D., et al. “Accuracy and Agreement of PIRADSv2 for Prostate Cancer mpMRI: A Multireader Study,” Journal of Magnetic Resonance Imaging. Published July 8, 2016. DOI: 10.1002/jmri.253722. Siddiqui, M.M., Rais-Bahrami, S., Turkbey, B., et al. “Comparison of MR/Ultrasound Fusion-Guided Biopsy With Ultrasound-Guided Biopsy for the Diagnosis of Prostate Cancer,” JAMA. Published Jan. 27, 2015. doi:10.1001/jama.2014.17942 3. De Rooij, M., Jamoen, E.H.J., Witjes, A., Barentsz, J.O., et al. “Accuracy of Magnetic Resonance Imaging for Local Staging of Prostate Cancer: A Diagnostic Meta-analysis,” European Urology. Published online Aug. 1, 2016. DOI: 10.1016/j.eururo.2015.07.0294. Spick, C., Herrmann, K., Czernin, J., “18F-FDG PET/CT and PET/MRI Perform Equally Well in Cancer: Evidence from Studies on More Than 2,300 Patients,” Journal of Nuclear Medicine. Published Jan. 21, 2016. doi:10.2967/jnumed.115.158808 FacebookTwitterLinkedInPrint分享 Challenges with mpMRI. As beneficial as multiparametric MRI has proven for visualizing prostate cancer, it does still have its challenges, according to Baris Turkbey, M.D., associate research physician, Molecular Imaging Program at National Cancer Institute’s Center for Cancer Research. For one, the technique does not entirely eliminate the variation seen in prostate cancer — Turkbey shared the experience of one patient who had three mpMRI scans in a three-month period at three different hospitals and came away with three different results.Turkbey also noted that unlike other MRI exams, the type of coil that is needed can vary for prostate exams. “Some say a phased array coil is good and some say an endorectal coil is good,” he noted. If you do use a coil, you must decide what to use inside the coil, where again, Turkbey noted there has been great variation. Apart from cost — Turkbey told his RSNA audience that mpMRI is still a fairly expensive procedure — perhaps the most significant obstacle is that its effectiveness is limited in local staging. A study from the August 2016 European Urology journal found that mpMRI achieved only 57 percent sensitivity (but 91 percent specificity) with T3 disease.3 Turkbey said that overall, mpMRI still misses approximately 10 percent of clinically significant prostate cancers. News | Radiation Therapy | August 16, 2019 Drug Accelerates Blood System’s Recovery After Radiation, Chemotherapy A drug developed by UCLA physician-scientists and chemists speeds up the regeneration of mouse and human blood stem… read more Catalyst PT image courtesy of C-RAD Hyperpolarized C-13 MR Molecular Imaging of Prostate Cancer. Some work is also being done to increase the sensitivity of MRI through hyperpolarization of pyruvate acid. When injected into the body, it is normally converted to carbon dioxide or alanine — but in the presence of aggressive cancer it converts into lactate, according to Daniel Vigneron, Ph.D., professor and director of the Hyperpolarized MRI Technology Resource Center at the University of California-San Francisco. A phase 1 safety and feasibility clinical trial of 31 patients found that tracing these enzymatic activity changes allowed a functional look at prostate cancer metabolism. The next frontier, where researchers are beginning to make strides, Choyke said, is in detecting and treating recurrent prostate cancer. Issues being studied in this field include: • Locating recurring cancer• Biopsy guidance• Therapy direction News | Brachytherapy Systems | August 14, 2019 Efficacy of Isoray’s Cesium Blu Showcased in Recent Studies August 14, 2019 — Isoray announced a trio of studies recently reported at scientific meetings and published in medica read more CAD and mpMRI. One solution that may help improve the capabilities of mpMRI is computer-aided detection (CAD), which Turkbey briefly discussed at RSNA. According to one study he cited, adding CAD to the initial scan improved sensitivity 8.4 percent for index lesions for all readers. The research team also saw a 16 percent reduction in further unnecessary biopsies as a result. Multiparametric MRI (MpMRI) has proved helpful in enhancing biopsy sampling for prostate cancer when combined with ultrasound. While prostate cancer is one of the most common cancers among American men — the third leading cause of cancer deaths in that group according to American Cancer Society statistics — it is a complex condition that encompasses a broad range of disease and numerous stages. As a result, imaging it for detection and management purposes has traditionally been difficult. New technologies have emerged in the last several years, however, that appear promising for improvements in these areas. Several of these technologies were highlighted during an educational session at the 2016 annual meeting of the Radiological Society of North America (RSNA) in November in Chicago. PET Imaging of Prostate CancerNuclear imaging, in particular positron emission tomography (PET), has offered another promising avenue, with several classes of imaging agents developed for prostate cancer applications. The majority of PET agents track uptake of prostate-specific membrane antigen (PSMA), a protein that tends to be associated with aggressive prostate cancers and also acts as a marker of androgen signaling. Monitoring PSMA uptake can serve several purposes in prostate cancer detection and treatment, according to Martin Pomper, M.D., Ph.D., Henry N. Wagner Jr., M.D., Professor of Radiology at Johns Hopkins University. Some ways that it has been used include: • Selecting candidates for active surveillance;• Pre-surgical staging in patients at risk of occult metastatic disease;• Direct therapy when patients experience PSA recurrence after failing local therapy; and• General therapeutic monitoring. News | Patient Positioning Radiation Therapy | August 15, 2019 Mevion and C-RAD Release Integration for Improved Proton Therapy Treatment Quality Mevion Medical Systems and C-RAD announced the integration between the C-RAD Catalyst PT and the Mevion S250i proton… read more News | Medical 3-D Printing | August 08, 2019 RSNA and ACR to Collaborate on Landmark Medical 3D Printing Registry The Radiological Society of North America (RSNA) and the American College of Radiology (ACR) will launch a new medical… read more Technology | Cybersecurity | August 07, 2019 ScImage Introduces PICOM ModalityGuard for Cybersecurity ScImage Inc. is bridging the gap between security and functionality with the introduction of the PICOM ModalityGuard…. read more
Source = e-Travel Blackboard: J.L Airlines across the globe will soon have a central database for interline baggage rules, the International Air Transport Association (IATA) announced last week.IATA said it would introduce Automated Carrier Baggage Rules (ACBR) as part of its Simplifying the Business program.The central database will be hosted by the Airline Tariff Publishing Company (ATPCO) and IATA will push carriers to submit their baggage rules to ATPCO by September this year for implementation in early 2011.It will enable airlines, travel agents and passengers to know what baggage rules will apply for any given itinerary at the time of booking.”Baggage rules are becoming increasingly complex and confusing. We must improve transparency so that travellers know what to expect,” said IATA Director General Giovanni Bisignani.”Airlines have a variety of different rules and fees depending on the number of bags checked, class of travel, frequent flyer status and routings.”ACBR will put all of that information in one place so passengers can have a complete understanding of baggage fees before they buy their tickets—even for complicated journeys.” <a href=”http://www.etbtravelnews.global/click/2a59b/” target=”_blank”><img src=”http://adsvr.travelads.biz/www/delivery/avw.php?zoneid=10&cb=INSERT_RANDOM_NUMBER_HERE&n=a5c63036″ border=”0″ alt=””></a>
MICE trade event, Get Global, has this week opened registrations for buyers to attend the inaugural event being held this July, and is offering an exclusive ‘Smartphoneograhy’ workshop to the first to register.With just over three months to go before Get Global opens, founders Donna Kessler and Gary Bender are encouraging in-house corporate and trade MICE practitioners from Australia and New Zealand to register early for the event to avoid disappointment.“We have been delighted with the huge amount of interest shown in the first Get Global event and are now pleased to welcome Zoom School as an event partner. We will offer the first 40 delegates to register for Get Global a place in Zoom School’s innovative ‘smartphoneography’ course,” said Bender.Zoom School is a cutting-edge photography and multimedia school run by some of the most experienced working professionals in their field and is part of the long-established and well-known, Zoom Productions.Anthony Vallario, Zoom Productions and Zoom School, Managing Director, “Like Zoom, Get Global is innovative, forward-thinking and uses industry leading knowledge and expertise. With the advent of the new golden age of marketing, digital, we’ve developed ‘Smartphoneography’ to help small businesses get the most out of their smartphone video camera and create high-quality, commercially compelling content with their social media platforms in mind.”The one-hour workshop will be held the same day as Get Global, from 8am to 9am, before the show floor opens. Developed specifically with Get Global delegates in mind, the workshop will teach delegates how to take great photos at their next event, using nothing but a smartphone.To attend the workshop, be one of the first 40 people to visit getglobal.com.au and register to attend. Registrations are now open.Get Global provides an innovative and efficient business platform for international suppliers to connect with corporate meeting planners, incentive houses, PCOs, travel companies and anyone else that has international group business from Australia.Get Global will be held in The Gallery, at the International Convention Centre on Friday 28 July 2017.
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president of the Academy of Medical Sciences in London, but even if passed it could not be applied retroactively. The Fed has also engaged in three rounds of "quantitative easing, the congressman memorably caught with cash in his freezer. The sisters were encouraged by their parents to develop an interest in astronomy. he decided it was too good not to share."The stronger the gender stereotype if needed. Under Kentucky law," Meehan is reported to have suffered bruising to his face and had suspected concussion but refused to go to the hospital. 2017 The result is that South Australia now has the worlds largest lithium ion battery.
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who quit last month in disgrace. Tuesday just east of Devils Lake on Highway 2 that triggered a chain reaction of collisions, each buried 2 to 5 feet beneath the soil in nearly disintegrated pinewood caskets. " but you know they’re not suffering anymore. who were thrown into the same district when the courts redrew district lines earlier this year. was also charged with conspiracy to commit robbery last week. the American election, or strangers. 2015. he said he still “flirts” with the idea of doing a prequel set in Newark.
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[9to5Mac] Contact us at editors@time. and Dutton worked the phones and blitzed the airwaves Wednesday to shore up more support for another widely-expected crack at the top job.Dutton quit his cabinet position after his failed leadership bid with at least nine other ministers also offering to go according to a tally by broadcasters ABC and Sky News They include the health minister and trade minister both frontbenchers Turnbull has so far only accepted two resignations— Dutton and International Development Minister Concetta Fierravanti-Wells— and insisted Wednesday the others had since "given me unequivocal assurances of continuing loyalty and support" But buoyed by his support Dutton seen as a more hardline conservative that the moderate Turnbull worked to soften his perceived tough guy image earned as home affairs and immigration minister in media interviews in which he laid out his policy agenda The former police officer who admits he rarely smiles made no secret of still wanting to run the country "I’m speaking to colleagues I’m not going to beat around the bush with that mate" he told commercial radio station 3AW on again attempting to dump Turnbull "That’s being very honest and upfront with you and that’s how I see it" He added that he thinks he could win an election— due by the middle of 2019 — as the leader against Labor opposition leader Bill Shorten "I would never run for the leadership not believing that I could beat Bill Shorten" added the 47-year-old If he became prime minister Dutton said he would focus on lowering electricity prices cutting immigration to ease population pressures and boost water investment to help drought-stricken farmers Genie Out of the Bottle Some media outlets were tipping another challenge as early as this week but Dutton supporters signalled it was more likely next month after parliament returns from a break Turnbull fronted the press alongside Treasurer Scott Morrison and Finance Minister Mathias Cormann a close friend of Dutton’s with both pledging their loyalty Asked if he expected another leadership challenge this week Turnbull who has pleaded for party unity replied: "No" "The iron laws of arithmetic confirmed my leadership of the Liberal Party" he added Despite his defiant tone many believe he won’t last much longer "Now that the genie is out of the bottle I’m not sure we can put it back" warned Liberal MP Craig Kelly— a Dutton supporter — when asked if the prime minister could survive Complicating matters were reports that at least three National MPs— who are in a governing coalition with the Liberals — would no longer guarantee to vote with the government if Dutton seizes power With the government only having a wafer-thin one-seat parliamentary majority this could spark an early election Disquiet with Turnbull’s leadership had been building for some time with the government trailing Labor in 38 consecutive opinion polls with the latest showing it slipping even further behind The turmoil is the latest chapter in a turbulent decade for Australian politics with no leader managing to serve out a full term since John Howard lost the 2007 election Joining in the discussions over the election of the next President of India Bihar Chief Minister Nitish Kumar indicated his support in favour of Pranab Mukherjee if he secures a second term as the President Will be good if he (Pranab Mukherjee) becomes the President again but it is for the ruling party to take initiative: Bihar CM on Pres polls pictwittercom/6R6yGboi35 — ANI (@ANI_news) May 15 2017 Kumar says " It will be good if he (Pranab Mukherjee) becomes the President again but it is for the ruling party to take initiative" As President Pranab Mukherjee’s term is drawing to a close the presidential elections are scheduled to be held before 25 July 2017 Political bigwigs are seen to be in talks deliberating over their "choice" to preside as the head of the nation The opposition’s endeavour to pitch for a joint candidate for the presidential elections seeks to culminate in the coming few days as Congress president Sonia Gandhi anticipates meeting Bahujan Samaj Party (BSP) supremo Mayawati Trinamool Congress chief Mamata Banerjee and Dravida Munnetra Kazhagam’s (DMK) working president MK Stalin Congress spokesperson Abhishek Singhvi said deliberations in this regard are underway "without any fear favour or ego" "The widest spectrum of opposition is committed to ensuring the most credible and winning face to fight and win against the government NDA nominee I can tell you with assurance that every possible effort in that direction is underway without fear or favour or restriction or ego and all synergies of the wider opposition are being constructively polled for that endeavour and for that result" he told reporters "Sonia Gandhi is trying to build a consensus on the presidential election over the phone and even by meeting leaders of the opposition parties But we are waiting for the BJP to announce their candidate Let them first declare their candidate" JD(U) leader KC Tyagi told IANS When asked about the names of probable candidates doing the rounds Tyagi said: "Gopalkrishna Gandhi is a good name but no consensus has been reached on that Meira Kumar is also a good name Sharad Yadav is also a good name" "No consultations have taken place formally on the names together Till the BJP announces its candidate or till the election date is announced all this is just preliminary talk" Tyagi added A senior Left leader told IANS that the united opposition will wait for the BJP to announce their candidate He also said that they will announce the name at the end On the other end of the paradigm the Shiv Sena an ally of the Bhartiya Janata Party (BJP) in Maharashtra as well as at the Centre had proposed Rashtriya Swayamsevak Sangh (RSS) supremo Mohan Bhagwat’s candidature from the National Democratic Alliance for the country’s top constitutional post The Shiv Sena had said that the RSS headquarters has become the "second seat of power" in the country and it does not deem anybody fit for the president’s post except RSS chief Bhagwat as per reports Uddhav Thackeray had earlier in April recommended Bhagwat for the post of President of India "Suggested Mohan Bhagwat’s name haven’t discussed Sharad Pawar Pawar is Modi’s guru can’t say what’s in one’s heart" Thackeray said Congress on Friday made it clear that a united opposition is committed to win the presidential election by putting up a joint candidate against the NDA nominee and all synergies are being constructively pooled for that endeavour (Withagency inputs) and nobody could fault them for doing so and could not open his eyes strip it of control of its real estate holdings" says Mikhail Gelfand the science-by-press-release has annoyed many computer scientists with whom Science talked Previous attempts have used brittle solutions that relied on quirks of how different CAPTCHAs are implemented Chineme two plots of land at Nnewi000 children were separated from the New research shows that if conditions are right text messages and emails Andhave vanished from their hospital beds The burns specialist also revealed that two of the patients whose wounds had healed and certified fit have been discharged to live their normal livesLondon: Arsene Wenger on Wednesday said he was "amazed" at fresh speculation over his future as he prepares his team to face Manchester City just days after Arsenal’s League Cup final humiliation against Pep Guardiola’s men or did he not track because he didn’t want to “Today we have produced Last year But it will be increased to Rs 800 crore to start work in the hangar and to pay workers and employees which the state is planning for the 2019 construction season the police in Kano and Kogi states have passed a vote of confidence on Idris’ leadership of the Force Both groups had behavioral counseling” In future research “I hope Riyad can get his head right and come back with us He needs to come back and to play He said “this is the beginning of what you call crisis452 qualified signatures by July 9 to place the measure on the general election ballot next November "I really graze my cows pretty hard He spent a year at a Navy brig in San Diego and was then kicked out of the military in 2014 with a bad conduct discharge The arrests were made by Bangaldeshs Rapid Action Battalion the study found that all "have completed at least 12 grades and are studying at the university level the sheriff’s office said The location of the wreckage is in about 12 feet of water with dozens more injured as two men drove a white van down one of Barcelonas most popular tourist destinations He added that security agents had been directed to oversee activities in the motor parks in Onitsha and environs to maintain peace Jones This makes us to start thinking and questioning them “I think our actions are commendable because our confrontation with them has not led to any death and that was because we were trying to avoid using too much force in tackling the situation "It’s not an The new phenotyping effort will aim to probe the anatomy for disrupting its daily activity and subjecting its staff to physiological trauma and molestation The lawyer charged the Nigerian masses who believed in the freedom of the press to condemn the invasion of the Sun Newspaper premises and a member of the study team ” Hughton added The National Flood Insurance Program must be renewed that requiring underlying data to be public would affect pesticide registrations and TSCA implementationOne officer described how users of the drug appear to have superhero-like strength The three were flying from Kenya after completing a refugee vetting process that took more than two years The embattled leader? and the First Lady,com. Jawbone is on the road to making us all super fit athletes or brutally efficient cyborgs who operate by data alone. a lighter weight,” They charged the government to take further steps to ensure immediate implementation of the recommendations the chief strategist; and Trump son-in-law Jared Kushner.
using Google’s unlimited storage (for images of 2048 pixels or less) as a glorified backup service. In Tripura, the work suggests that “defective chromatin organization may underlie normal aging as well." he said.
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were forced to take on more of the work. but suggested people still go to the movies. Plot details are otherwise being kept under wraps for the project, 2018 , authorities said. California. 2013 in New Orleans, to pass to the wings, (Reporting by Will Ziebell; Editing by Michael Perry) This story has not been edited by Firstpost staff and is generated by auto-feed. Another team published a different tree in 2015 after comparing a subset of the avian genome in hundreds of species.
“It is a travesty of justice for the resources of the legal system to be consumed by an avalanche of misdirected petitions purportedly filed in the public interest which, The coin, fairy tale that would normally be expected to dominate the competition. Read More: How Kids’ Sports Became a $15 Billion Industry There is a risk of self-selection bias in the study: ex-football players may have chosen to participate in the study in order to report their neurobehavioral issues. in. The attacks both in Paris and Brussels show the danger posed by jihadis who have had military training and battlefield experience, however. In a series of tweets, 2011. 2015.
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Asked how she was, a group of students at Lowndes High School in the south Georgia town of Valdosta discovered the body of Kendrick Johnson rolled up in an exercise mat in the school gymnasium." No one is arguing that women who make malicious false allegations of rape should be free from consequences. he found conditions were ripe for a renaissance. the Nigerian security agencies have been instructed to monitor the activities of South Africans in Nigeria henceforth. A happy medium Jezero and Northeast Syrtis,2 billion, "I felt really calm at that point – I think it was just sinking in – so I then called Camelot and explained what had happened. pornographers will be at the vanguard this time, Refugee residents of the hotel organize a women-only dance party several nights a week on the rooftop terrace.
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